Tg(Lck-Nr4a1)2Brv
Transgene Detail

Summary

• Symbol: Tg(Lck-Nr4a1)2Brv
• Name: transgene insertion 2, Rodrigo Bravo
• MGI ID: MGI:2386333
• Synonyms: Nur77/N10^TG, nur77^Tg
• Transgene: Tg(Lck-Nr4a1)2Brv Location: unknown
• Alliance: Tg(Lck-Nr4a1)2Brv page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Lck-Nr4a1)2Brv expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nr4a1 (MGI:1352454)

• Mutation details: The mouse Nr4a1 cDNA fused to a mouse Lck proximal promoter was used as the transgene. Northern and Western blot analyses of thymus and thymocytes showed that RNA and protein expression is significantly increased in transgenic animals. Nuclear extracts from transgenic thymocytes also showed stronger DNA-binding activity compared to wild-type. (J:78762)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Founder 2 is representative of transgenic founders 2 and 4 exhibiting the highest levels of transgene expression that were used for analysis.

References

• Original: J:78762 Weih F, et al., Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5533-8
• All: 2 reference(s)