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Igf1rtm1.2Mhz
Targeted Allele Detail
Nomenclature
Symbol: Igf1rtm1.2Mhz
Name: insulin-like growth factor I receptor; targeted mutation 1.2, Martin Holzenberger
MGI ID: MGI:2386329
Synonyms: IGF-1R-, IGF-IRex3-, Igfr1-
Gene: Igf1r  Location: Chr7:67952827-68233668 bp, + strand  Genetic Position: Chr7, 37.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63460
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe in vivo expression of cre recombinase via the EIIa promoter resulted in the excision of a floxed fragment containing a neo cassette and exon 3 from Igf1rtm1Mhz. (J:63460)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Igf1r Mutation:  40 strains or lines available
References
Original:  J:63460 Holzenberger M, et al., A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit. Endocrinology. 2000 Jul;141(7):2557-66
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory