All Phenotypes Igf1r<tm1.2Mhz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igf1r^tm1.2Mhz
targeted mutation 1.2, Martin Holzenberger
MGI:2386329

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igf1r^tm1.2Mhz/Igf1r^tm1.2Mhz	involves: 129/Sv * C57BL/6 * FVB/N	MGI:3775301
cx2	Igf1r^tm1.2Mhz/Igf1r⁺ Zfand2b^tm1Otin/Zfand2b^tm1Otin	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6	MGI:6784094

Allelic Composition	Igf1r^tm1.2Mhz/Igf1r^tm1.2Mhz
Genetic Background	involves: 129/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1.2Mhz mutation (1 available); any Igf1r mutation (86 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:63460 )

• at birth mice cannot breath and die within the first few minutes of life

respiratory system

respiratory failure ( J:63460 )

• at birth mice cannot breath

growth/size/body

decreased body weight ( J:63460 )

• mice are 50.3% of wild-type weight

muscle

abnormal muscle morphology ( J:63460 )

• mice exhibit general hypotrophia with particularly underdeveloped intercostals muscles

Allelic Composition	Igf1r^tm1.2Mhz/Igf1r⁺ Zfand2b^tm1Otin/Zfand2b^tm1Otin
Genetic Background	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1r^tm1.2Mhz mutation (1 available); any Igf1r mutation (86 available)
Zfand2b^tm1Otin mutation (0 available); any Zfand2b mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:233169 )

• mice exhibit normal spleen weight with no significant alterations in hematocrit and WBC, lymphocyte, granulocyte or platelet number in peripheral blood relative to wild-type or single Igf1r^tm1.2Mhz heterozygous controls at 6 and 12 months of age

• normal % and absolute number of LSK+ cells in bone marrow and spleen with no evidence of reticulin fibers (myelofibrosis) in bone marrow at 12 months of age, unlike in Zfand2b^tm1Otin homozygotes

• normal total number of bone marrow cells, with no significant differences in the number of mature myeloid cells or nucleated red cells relative to wild-type or single Igf1r^tm1.2Mhz heterozygous controls

neoplasm

neoplasm ( J:233169 )

N	• mice do NOT develop myeloproliferative neoplasms, unlike Zfand2b^tm1Otin homozygotes

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