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Ikbkgtm1Mpa
Targeted Allele Detail
Nomenclature
Symbol: Ikbkgtm1Mpa
Name: inhibitor of kappaB kinase gamma; targeted mutation 1, Manolis Pasparakis
MGI ID: MGI:2386324
Synonyms: NemoD, Nemohko
Gene: Ikbkg  Location: ChrX:74393290-74453854 bp, + strand  Genetic Position: ChrX, 38.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63055
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsFlanking loxP sites were introduced to exon 2 and an FRT-flanked neomycin resistance cassette was inserted into the downstream intron via homologous recombination. Deletion of exon 2 and the neo cassette was carried out by transient expression of cre and flp recombinases in correctly targeted ES cells. Western blot analysis of mouse embyonic fibroblasts cultured from E12.5 homozygous mutant embryos confirmed the null allele. It was also shown that the targeted mutation did not interfere with neighboring gene G6pdx. (J:63055)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbkg Mutation:  12 strains or lines available
References
Original:  J:63055 Schmidt-Supprian M, et al., NEMO/IKK gamma-deficient mice model incontinentia pigmenti. Mol Cell. 2000 Jun;5(6):981-92
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory