Mmp3^tm1Mrl
Targeted Allele Detail

Summary

• Symbol: Mmp3^tm1Mrl
• Name: matrix metallopeptidase 3; targeted mutation 1, Merck Research Laboratory
• MGI ID: MGI:2386262
• Synonyms: MMP-3 -, SLN1-deficient
• Gene: Mmp3 Location: Chr9:7445822-7455975 bp, + strand Genetic Position: Chr9, 2.46 cM
• Alliance: Mmp3^tm1Mrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46038
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The zinc-binding site was deleted by replacement of partial exon 3 and entire exon 4 with a neomycin resistance cassette via homologous recombination. Inactivation of the gene was confirmed via Northern blot analysis of Il1a- and Il1b-stimulated primary embryonic fibroblasts derived from homozygous mutant animals. (J:46038)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp3 Mutation: 32 strains or lines available

References

• Original: J:46038 Mudgett JS, et al., Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destruction. Arthritis Rheum. 1998 Jan;41(1):110-21
• All: 41 reference(s)