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Igfalstm1Yrb
Targeted Allele Detail
Nomenclature
Symbol: Igfalstm1Yrb
Name: insulin-like growth factor binding protein, acid labile subunit; targeted mutation 1, Yves R Boisclair
MGI ID: MGI:2386180
Synonyms: ALSKO
Gene: Igfals  Location: Chr17:24878770-24882008 bp, + strand  Genetic Position: Chr17, 12.53 cM, cytoband A2-A3
Igf1tm1Dlr/Igf1tm1Dlr Igfalstm1Yrb/Igfalstm1Yrb Tg(Alb1-cre)1Dlr/? mice exhibit reduced growth plate height

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62710
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igfals Mutation:  3 strains or lines available
References
Original:  J:62710 Ueki I, et al., Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6868-73
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory