Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igfalstm1Yrb mutation
(1 available);
any
Igfals mutation
(33 available)
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growth/size/body
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• body weight normal from birth to 14 days of age
• lighter weight by 15 days of age becoming significant by age 21 days
• maximum weight difference was 13% at age 70 days
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reproductive system
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• litter sizes were slightly reduced
• nurturing behavior of mothers was normal otherwise
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igfalstm1Yrb mutation
(1 available);
any
Igfals mutation
(33 available)
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skeleton
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• reduced cortical bone thickness
• 24% reduction in cortical bone volume and reduced trabecular bone volume
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limbs/digits/tail
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• reduced cortical bone thickness
• 24% reduction in cortical bone volume and reduced trabecular bone volume
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Igf1tm1Dlr/Igf1tm1Dlr Igfalstm1Yrb/Igfalstm1Yrb Tg(Alb1-cre)1Dlr/? mice exhibit reduced growth plate height
growth/size/body
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• 30% reduction in total length by 2-3 weeks of age
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skeleton
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• reduced cortical bone thickness
• reduced trabecular bone volume and trabecular bone density
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• 20% shorter at 21 days of age and 12% shorter at 6 weeks of age
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• tibial growth plate height reduced by 20%
• germinal zone height increased in the tibia
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limbs/digits/tail
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• reduced cortical bone thickness
• reduced trabecular bone volume and trabecular bone density
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• 20% shorter at 21 days of age and 12% shorter at 6 weeks of age
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Analysis Tools