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Eportm1.4Jtp
Targeted Allele Detail
Nomenclature
Symbol: Eportm1.4Jtp
Name: erythropoietin receptor; targeted mutation 1.4, Josef T Prchal
MGI ID: MGI:2386099
Synonyms: EporTr, mthEPOR
Gene: Epor  Location: Chr9:21958899-21963576 bp, - strand  Genetic Position: Chr9, 7.93 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67205
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThis allele is a derivative of Eportm1.3Jtp in which cre-mediated recombination in vivo removed the PGK-neo cassette in the germline. The resulting allele, Eportm1.4Jtp, contains human sequence carrying a C5964G transversion mutation in exon 8. RT-PCR analysis of bone marrow detected truncated human transcript in homozygous mutant mice. (J:67205)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epor Mutation:  3 strains or lines available
References
Original:  J:67205 Divoky V, et al., Mouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor gene. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):986-91
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory