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Targeted Allele Detail
Symbol: Hrastm1Esn
Name: Harvey rat sarcoma virus oncogene; targeted mutation 1, Eugenio Santos
MGI ID: MGI:2385945
Synonyms: H-ras-
Gene: Hras  Location: Chr7:141189105-141194005 bp, - strand  Genetic Position: Chr7, 86.48 cM
Germline Transmission:  Earliest citation of germline transmission: J:67374
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1, 2, and 3 were replaced by a neomycin selection cassette via homologous recombination. Homozygous mutant mice were shown to lack transcript by RT-PCR analysis. Western blot analysis showed that the mutant allele did not lead to the produciton of protein. (J:67374)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hras Mutation:  24 strains or lines available
Original:  J:67374 Esteban LM, et al., Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development. Mol Cell Biol. 2001 Mar;21(5):1444-52
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory