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Targeted Allele Detail
Symbol: Hsd11b1tm1Yko
Name: hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1, Yuri V Kotelevtsev
MGI ID: MGI:2385796
Synonyms: 11beta-HSD-1-, 11beta-HSD1-, HSD1-
Gene: Hsd11b1  Location: Chr1:193221634-193264075 bp, - strand  Genetic Position: Chr1, 97.67 cM
Hsd11b1tm1Yko/Hsd11b1tm1Ykomice show lipid accumulation in the liver

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:37960
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette containing a human beta actin promoter replaced a genomic sequence encompassing exons 3 and 4. Northern blot analyses of liver and brain did not detect mRNA in homozygous mutant mice. Enzyme function analyses of tissues from homozygous mutant mice detected less than 5% of wild-type enzyme levels in liver and did not detect enzyme in brain. (J:45085)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsd11b1 Mutation:  7 strains or lines available
Original:  J:37960 Kotelevtsev YV, et al., Inactivation of 11 beta-hydroxysteroid dehydrogenase type 1 by gene targeting in mice. Endocr Res. 1996;22(4):791-792
All:  29 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory