Tg(SFTPC-FGFR2)1Lwi
Transgene Detail

Summary

• Symbol: Tg(SFTPC-FGFR2)1Lwi
• Name: transgene insertion 1, Lewis Williams
• MGI ID: MGI:2385682
• Transgene: Tg(SFTPC-FGFR2)1Lwi Location: unknown
• Alliance: Tg(SFTPC-FGFR2)1Lwi page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F1

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SFTPC-FGFR2)1Lwi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  FGFR2 (2263)

  Fgfr2

  (MGI:95523)

  Expresses a 1.3 kb fragment of truncated human FGFR2-IIIb cDNA deleted for kinase domains 1 and 2

• Tg(SFTPC-FGFR2)1Lwi expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  SFTPC (6440)

  Sftpc

  (MGI:109517)

• Mutation details: 1.3 kb of truncated human FGFR2-IIIb cDNA deleted for kinase domains 1 and 2 was used as the transgene. Deletion of the kinase domains results in a dominant negative protein which blocks FGF receptor signaling. The transgene is expressed in developing airway epithelium under the direction of the human SFTPC promoter. Expression of the transgene was detected in the distal epithelial cells of the lung via in situ hybridization analysis. (J:19481)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:19481 Peters K, et al., Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung. EMBO J. 1994 Jul 15;13(14):3296-301
• All: 1 reference(s)