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Targeted Allele Detail
Symbol: Il4tm1Rao
Name: interleukin 4; targeted mutation 1, Anjana Rao
MGI ID: MGI:2384290
Synonyms: V/Valpha KO
Gene: Il4  Location: Chr11:53612460-53618665 bp, - strand  Genetic Position: Chr11, 31.97 cM
Germline Transmission:  Earliest citation of germline transmission: J:78089
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutation:    Intragenic deletion
Mutation details3.7 kb of sequence in the intergenic region 3' of Il4 was replaced with a floxed neo cassette. The deleted region contained DNAse I hypersensitivity sites V and Va. These sites contain enhancers for Il4 transcription. The neo expression cassette was excised in vitro via the expression of cre recombinase. T lymphocytes and mast cells from homozygous mutant mice express reduced Il4 mRNA and protein. (J:78089)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il4 Mutation:  29 strains or lines available
Original:  J:78089 Solymar DC, et al., A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity. 2002 Jul;17(1):41-50
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory