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Cdkn2atm1.1Brn
Targeted Allele Detail
Nomenclature
Symbol: Cdkn2atm1.1Brn
Name: cyclin-dependent kinase inhibitor 2A; targeted mutation 1.1, Anton Berns
MGI ID: MGI:2384165
Synonyms: Ink4a-, Ink4a*, p16-, p16Ink4a--, p16Ink4a*, p16Ink4a KO
Gene: Cdkn2a  Location: Chr4:89274471-89294653 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71393
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThis allele was generated by excising the floxed neo cassette from Cdkn2atm1Brn by breeding with transgenic mice expressing cre. The presence of a stop codon at position 101 of the p16Ink4a open reading frame precluded the translation of the fourth ankyrin motif of p16Ink4a. While p16Ink4a was undetected by Western blot analysis or immunoprecipitation, the expression of p19ARF was unaffected in homozygous mutant mice. (J:71393)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:  23 strains or lines available
References
Original:  J:71393 Krimpenfort P, et al., Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature. 2001 Sep 6;413(6851):83-6
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory