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Targeted Allele Detail
Symbol: Lortm1Der
Name: loricrin; targeted mutation 1, Dennis R Roop
MGI ID: MGI:2384073
Synonyms: Lor-
Gene: Lor  Location: Chr3:92080271-92083142 bp, - strand  Genetic Position: Chr3, 40.14 cM
Delayed development of the skin barrier in Lortm1Der/Lortm1Der embryos

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:65187
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region of the endogenous locus was replaced with a neomycin selection cassette. The absence of transcript and protein was verified via RNAse protection assays, Western blot analysis, and indirect immunofluoresence microscopy. (J:65187)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lor Mutation:  4 strains or lines available
Original:  J:65187 Koch PJ, et al., Lessons from loricrin-deficient mice. Compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. J Cell Biol. 2000 Oct 16;151(2):389-400
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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