Phenotypes associated with this allele

• Allele Symbol: Loricrin^tm1Der
• Allele Name: targeted mutation 1, Dennis R Roop
• Allele ID: MGI:2384073
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Loricrin^tm1Der/Loricrin^tm1Der	FVB.129S7-Loricrin^tm1Der	MGI:3582394

Genotype
MGI:3582394

hm1

• Allelic Composition: Loricrin^tm1Der/Loricrin^tm1Der
• Genetic Background: FVB.129S7-Loricrin^tm1Der

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Delayed development of the skin barrier in Loricrin^tm1Der/Loricrin^tm1Der embryos

growth/size/body

decreased body size ( J:65187 )

• runted at birth

homeostasis/metabolism

impaired skin barrier function ( J:65187 )

• develops a day late at E17.5

immune system

erythroderma ( J:65187 )

• mutants develop a transient congenital erythroderma

integument

impaired skin barrier function ( J:65187 )

• develops a day late at E17.5

erythroderma ( J:65187 )

• mutants develop a transient congenital erythroderma

abnormal epidermis stratum corneum morphology ( J:65187 )

• cornified cell envelopes are irregular in shape

translucent skin ( J:65187 )

• shiny, translucent skin at birth

• skin phenotype persists for 4-5 days then gradually disappears

abnormal skin condition ( J:65187 )

decreased skin tensile strength ( J:65187 )

• cornified cell envelope of epidermis is more sensitive to mechanical stress, particularly at 4C