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Snrpntm2Alb
Targeted Allele Detail
Nomenclature
Symbol: Snrpntm2Alb
Name: small nuclear ribonucleoprotein N; targeted mutation 2, Arthur L Beaudet
MGI ID: MGI:2384039
Synonyms: del4.8, PW-ICdelta4.8
Gene: Snrpn  Location: Chr7:59982502-60140219 bp, - strand  Genetic Position: Chr7, 34.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70275
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snrpn Mutation:  7 strains or lines available
Notes
Animals carrying the mutation on a paternally derived chromosome exhibit severe growth retardation and 40%-45% die before weaning. Animals carrying the mutation on a maternally derived chromosome develop normally.

References
Original:  J:70275 Bressler J, et al., The SNRPN promoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice. Nat Genet. 2001 Jul;28(3):232-40
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory