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Snrpntm1Alb
Targeted Allele Detail
Nomenclature
Symbol: Snrpntm1Alb
Name: small nuclear ribonucleoprotein N; targeted mutation 1, Arthur L Beaudet
MGI ID: MGI:2384038
Synonyms: 0.9 kb deletion, del0.9
Gene: Snrpn  Location: Chr7:59982495-60005111 bp, - strand  Genetic Position: Chr7, 34.04 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70275
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 0.9 kb region of the gene encompassing exon 1 was replaced with a floxed tk-neo cassette via homologous recombination. The tk-neo cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Mutant animals were identified by Southern blot analysis. Northern blot analysis showed significantly reduced gene expression in animals carrying the mutation on a paternally derived chromosome, but not when the animals carried the mutation on a maternally derived chromosome. (J:70275)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Snrpn Mutation:  13 strains or lines available
References
Original:  J:70275 Bressler J, et al., The SNRPN promoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice. Nat Genet. 2001 Jul;28(3):232-40
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory