Snrpn^tm1Alb
Targeted Allele Detail

Summary

• Symbol: Snrpn^tm1Alb
• Name: small nuclear ribonucleoprotein N; targeted mutation 1, Arthur L Beaudet
• MGI ID: MGI:2384038
• Synonyms: 0.9 kb deletion, del^0.9
• Gene: Snrpn Location: Chr7:59632243-59789967 bp, - strand Genetic Position: Chr7, 34.04 cM
• Alliance: Snrpn^tm1Alb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70275
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.9 kb region of the gene encompassing exon 1 was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Northern blot analysis showed significantly reduced gene expression in animals carrying the mutation on a paternally derived chromosome, but not when the animals carried the mutation on a maternally derived chromosome. (J:70275)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Snrpn Mutation: 23 strains or lines available

References

• Original: J:70275 Bressler J, et al., The SNRPN promoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice. Nat Genet. 2001 Jul;28(3):232-40
• All: 3 reference(s)