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Fcer1atm1Knt
Targeted Allele Detail
Nomenclature
Symbol: Fcer1atm1Knt
Name: Fc receptor, IgE, high affinity I, alpha polypeptide; targeted mutation 1, Jean-Pierre Kinet
MGI ID: MGI:2383982
Synonyms: FcepsilonR1alpha-, FcepsilonRI-, Fc epsilon RI alpha chain-, Fcer1a-, Fcer1atm1Rav, FcerIa-
Gene: Fcer1a  Location: Chr1:173221284-173227214 bp, - strand  Genetic Position: Chr1, 80.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39250
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 4, encoding an immunoglobulin domain, was disrupted by the insertion of a neomycin selection cassette. The absence of a functional encoded protein on the cell surface was determined by fluorescence activated cell sorting analysis of bone marrow mast cells obtained from homozygous mutant mice. (J:39250)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Fcer1a Mutation:  8 strains or lines available
Notes
ES cell line = D3 (129S2/SvPas) or E14TG2a (129P2/OlaHsd).
References
Original:  J:39250 Dombrowicz D, et al., Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene. Cell. 1993 Dec 3;75(5):969-76
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory