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Rad52tm1Aps
Targeted Allele Detail
Nomenclature
Symbol: Rad52tm1Aps
Name: RAD52 homolog, DNA repair protein; targeted mutation 1, Albert Pastink
MGI ID: MGI:2383953
Synonyms: MmRAD52-
Gene: Rad52  Location: Chr6:119902698-119922828 bp, + strand  Genetic Position: Chr6, 56.86 cM, cytoband G3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50357
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 was replaced with a neomycin selection cassette. Western blot analysis of homozygous mutant ES cells showed an absence of both normal and truncated protein. (J:50357)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rad52 Mutation:  11 strains or lines available
References
Original:  J:50357 Rijkers T, et al., Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation. Mol Cell Biol. 1998 Nov;18(11):6423-9
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory