About   Help   FAQ
Cdc7tm1Hmas
Targeted Allele Detail
Nomenclature
Symbol: Cdc7tm1Hmas
Name: cell division cycle 7 (S. cerevisiae); targeted mutation 1, Hisao Masai
MGI ID: MGI:2183930
Synonyms: muCdc7-
Gene: Cdc7  Location: Chr5:106964322-106984432 bp, + strand  Genetic Position: Chr5, 51.43 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76497
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 and 4 encoding kinase domains I and II were replaced with a neomycin resistance cassette via homologous recombination. Western blot analysis of heterozygous ES cells did not detect aberrant protein products. (J:76497)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdc7 Mutation:  21 strains or lines available
Notes
ES cell line = CCE 28.
References
Original:  J:76497 Kim JM, et al., Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death. EMBO J. 2002 May 1;21(9):2168-79
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/11/2017
MGI 6.10
The Jackson Laboratory