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Cdc7tm1Hmas
Targeted Allele Detail
Nomenclature
Symbol: Cdc7tm1Hmas
Name: cell division cycle 7 (S. cerevisiae); targeted mutation 1, Hisao Masai
MGI ID: MGI:2183930
Synonyms: muCdc7-
Gene: Cdc7  Location: Chr5:106964322-106984432 bp, + strand  Genetic Position: Chr5, 51.43 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76497
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 and 4 encoding kinase domains I and II were replaced with a neomycin resistance cassette via homologous recombination. Western blot analysis of heterozygous ES cells did not detect aberrant protein products. (J:76497)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdc7 Mutation:  15 strains or lines available
Notes
ES cell line = CCE 28.
References
Original:  J:76497 Kim JM, et al., Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death. EMBO J. 2002 May 1;21(9):2168-79
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory