All Phenotypes Cdc7<tm1Hmas> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdc7^tm1Hmas/Cdc7^tm1Hmas	involves: 129S/Sv * C57BL/6	MGI:2662266
cx2	Cdc7^tm1Hmas/Cdc7^tm1Hmas Trp53^tm2Mok/Trp53^tm2Mok	involves: 129S/Sv * C57BL/6	MGI:2662267
cx3	Cdc7^tm1Hmas/Cdc7^tm1Hmas Tg(EF1A-Cdc7)DKO28Hmas/0	involves: 129S/Sv * C57BL/6	MGI:2681167
cx4	Cdc7^tm1Hmas/Cdc7^tm1Hmas Tg(EF1A-Cdc7)DKO28Hmas/Tg(EF1A-Cdc7)DKO28Hmas	involves: 129S/Sv * C57BL/6	MGI:2681170

Allelic Composition	Cdc7^tm1Hmas/Cdc7^tm1Hmas
Genetic Background	involves: 129S/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc7^tm1Hmas mutation (0 available); any Cdc7 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:76497 )

• mutant embryos die between E3.5-E6.5

embryo

inner cell mass degeneration ( J:76497 )

• blastocysts grown in culture exhibit a smaller inner cell mass at E6 that continues to diminish in size such that by E8.5 it has disappeared

Allelic Composition	Cdc7^tm1Hmas/Cdc7^tm1Hmas Trp53^tm2Mok/Trp53^tm2Mok
Genetic Background	involves: 129S/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc7^tm1Hmas mutation (0 available); any Cdc7 mutation (34 available)
Trp53^tm2Mok mutation (2 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning, complete penetrance ( J:76497 )

• mutant embryos die around E8.5

embryo

decreased embryo size ( J:76497 )

growth/size/body

decreased embryo size ( J:76497 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:85942 )

• about 75% of mice born die within 3 days

• less than 25% survived to adulthood

• survivors have a normal life span

prenatal lethality, incomplete penetrance ( J:85942 )

• very few mice born

cellular

multinucleated giant male germ cells ( J:85942 )

abnormal cell cycle ( J:85942 )

• mouse embryo fibroblast growth slowed considerably

• fewer cells in S phase

• larger numbers of cells in G₀ or G₁

decreased DNA replication ( J:85942 )

• reduced rate of DNA replication

endocrine/exocrine glands

absent ovarian follicles ( J:85942 )

• lack oocytes and follicles

small ovary ( J:85942 )

• ovaries are small and grossly malformed

abnormal seminiferous tubule morphology ( J:85942 )

• reduced number of seminiferous tubules

• reduced spermatogonia

• degenerating primary spermatocytes

• high levels of apoptosis

small testis ( J:85942 )

growth/size/body

decreased body size ( J:85942 )

• mice that survive to adulthood are 50-55% normal size

• major organs are proportional

immune system

immune system phenotype ( J:85942 )

N	• thymic and periferral lymphocytes normal

limbs/digits/tail

curly tail ( J:85942 )

• tail flexion anomalies similar to curly-tail (ct) mice

reproductive system

abnormal female reproductive system morphology ( J:85942 )

absent ovarian follicles ( J:85942 )

• lack oocytes and follicles

small ovary ( J:85942 )

• ovaries are small and grossly malformed

abnormal gametogenesis ( J:85942 )

multinucleated giant male germ cells ( J:85942 )

arrest of male meiosis ( J:85942 )

• total absence of post meiotic cells

• failure in prophase I probably in zygotene stage

abnormal male reproductive system morphology ( J:85942 )

abnormal seminiferous tubule morphology ( J:85942 )

• reduced number of seminiferous tubules

• reduced spermatogonia

• degenerating primary spermatocytes

• high levels of apoptosis

small testis ( J:85942 )

homeostasis/metabolism

decreased DNA replication ( J:85942 )

• reduced rate of DNA replication

Allelic Composition	Cdc7^tm1Hmas/Cdc7^tm1Hmas Tg(EF1A-Cdc7)DKO28Hmas/Tg(EF1A-Cdc7)DKO28Hmas
Genetic Background	involves: 129S/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc7^tm1Hmas mutation (0 available); any Cdc7 mutation (34 available)
Tg(EF1A-Cdc7)DKO28Hmas mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:85942 )

• mouse embryo fibroblast proliferation and DNA synthesis essentially normal

• body weights normal

• males were fertile

• spermatogenesis restored

• testes remain small

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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