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Tg(App)1874Kha
Transgene Detail
Summary
Symbol: Tg(App)1874Kha
Name: transgene insertion 1874, Karen Hsiao Ashe
MGI ID: MGI:2183639
Synonyms: moAPPwt, Tg1874, Tg(App)1874Kahs, Tg(MoAPP695.WT)1874
Transgene: Tg(App)1874Kha  Location: unknown  
Alliance: Tg(App)1874Kha page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(App)1874Kha expresses 1 gene
 
Mutation detailsOverexpression of mouse App gene encoding App695.WT (wild-type). The construct contained the App gene fused to the hamster prion protein promoter. App expression was measured in brains of transgenic mice by quantitation of immunoblots. This transgenic line was estimated to contain ~31 copies of the transgene. Other lines generated using this construct varied in copy number and severity of phenoytpe. (J:29880)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:29880 Hsiao KK, et al., Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron. 1995 Nov;15(5):1203-18
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory