Phenotypes associated with this allele

• Allele Symbol: Tg(App)1874Kha
• Allele Name: transgene insertion 1874, Karen Hsiao Ashe
• Allele ID: MGI:2183639
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(App)1874Kha/?	FVB/N-Tg(App)1874Kha	MGI:2385755

Genotype
MGI:2385755

tg1

• Allelic Composition: Tg(App)1874Kha/?
• Genetic Background: FVB/N-Tg(App)1874Kha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:29880 )

• 50% of mutant mice are dead at 119 days of age

behavior/neurological

abnormal anxiety-related response ( J:29880 )

• 54% of mutant mice are neophobic at 100 days of age

nervous system

abnormal astrocyte morphology ( J:29880 )

• hypertrophic astrocytes observed in the parahippocampal area, hippocampus, amygdala, and cerebral cortex