About   Help   FAQ
Gna12tm1Citb
Targeted Allele Detail
Nomenclature
Symbol: Gna12tm1Citb
Name: guanine nucleotide binding protein, alpha 12; targeted mutation 1, California Institute of Technology - Biology
MGI ID: MGI:2183606
Synonyms: Galpha12-, Gna12-
Gene: Gna12  Location: Chr5:140759944-140830431 bp, - strand  Genetic Position: Chr5, 79.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77728
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsApproximately one-third of the coding sequence was replaced with a neomycin selection cassette into exon 4. A trunctated transcript was identified in homozygous mutant mice by Northern blot and RT-PCR analyses. Western blot analysis, using antibodies directed against the amino and carboxy termini, showed the absence of protein. (J:77728)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gna12 Mutation:  4 strains or lines available
References
Original:  J:77728 Gu JL, et al., Interaction of G alpha(12) with G alpha(13) and G alpha(q) signaling pathways. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9352-7
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/10/2020
MGI 6.16
The Jackson Laboratory