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Targeted Allele Detail
Symbol: Gna12tm1Citb
Name: guanine nucleotide binding protein, alpha 12; targeted mutation 1, California Institute of Technology - Biology
MGI ID: MGI:2183606
Synonyms: Galpha12-, Gna12-
Gene: Gna12  Location: Chr5:140759944-140830431 bp, - strand  Genetic Position: Chr5, 79.3 cM
Germline Transmission:  Earliest citation of germline transmission: J:77728
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsApproximately one-third of the coding sequence was replaced with a neomycin selection cassette into exon 4. A trunctated transcript was identified in homozygous mutant mice by Northern blot and RT-PCR analyses. Western blot analysis, using antibodies directed against the amino and carboxy termini, showed the absence of protein. (J:77728)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gna12 Mutation:  4 strains or lines available
Original:  J:77728 Gu JL, et al., Interaction of G alpha(12) with G alpha(13) and G alpha(q) signaling pathways. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9352-7
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory