Gapdh^m1Neu
Chemically induced Allele Detail

Summary

• Symbol: Gapdh^m1Neu
• Name: glyceraldehyde-3-phosphate dehydrogenase; mutation 1, Neuherberg
• MGI ID: MGI:2183515
• Synonyms: Gapd^1Neu, GAPDH 525
• Gene: Gapdh Location: Chr6:125138812-125143450 bp, - strand Genetic Position: Chr6, 59.32 cM, cytoband C
• Alliance: Gapdh^m1Neu page

Mutation origin

• Strain of Origin: (101/El x C3H/El)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An ENU induced mutation that was shown to express 50% of normal levels of the encoded enzyme in heterozygous mice. The mutation has been shown to be a T to A transversion at position 276 in exon2. This changes the codon 91 from a tyrosine to a stop codon. A truncated protein oof 89 amino acids should be produced. (J:126359)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gapdh Mutation: 40 strains or lines available

References

• Original: J:15477 Charles DJ, et al., Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice. Mutat Res. 1987 Jan;176(1):81-91
• All: 4 reference(s)