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Nthl1tm1Yas
Targeted Allele Detail
Nomenclature
Symbol: Nthl1tm1Yas
Name: nth (endonuclease III)-like 1 (E.coli); targeted mutation 1, Akira Yasui
MGI ID: MGI:2183467
Synonyms: mNth1 -, Nth1-
Gene: Nthl1  Location: Chr17:24632682-24638838 bp, + strand  Genetic Position: Chr17, 12.42 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77767
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 and 4, encoding the conserved helix-hairpin-helix domain, were deleted by the insertion of a neomycin selection cassette. The absence of full-length transcript was verifed via RT-PCR analysis. The expression of the adjacent Tsc2 was unaffected. Sequence analysis revealed that should an aberrantly spliced transcript arise via readthrough of the neo transgene, the splicing of exon 2 to exon 5 would generate a frameshift mutation that precludes production of a functional protein. (J:77767)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nthl1 Mutation:  4 strains or lines available
References
Original:  J:77767 Takao M, et al., Novel nuclear and mitochondrial glycosylases revealed by disruption of the mouse Nth1 gene encoding an endonuclease III homolog for repair of thymine glycols. EMBO J. 2002 Jul 1;21(13):3486-93
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory