S1pr2^tm1Jch
Targeted Allele Detail

Summary

• Symbol: S1pr2^tm1Jch
• Name: sphingosine-1-phosphate receptor 2; targeted mutation 1, Jerold Chun
• MGI ID: MGI:2183402
• Synonyms: s1p2^-
• Gene: S1pr2 Location: Chr9:20877248-20888089 bp, - strand Genetic Position: Chr9, 7.68 cM
• Alliance: S1pr2^tm1Jch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77809
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame, contained entirely in exon 2, was replaced with a neomycin selection cassette. The absence of transcript in homozygous mutant mice was determined via Northern blot analysis of heart, brain, lung, and spleen tissue. (J:77809)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any S1pr2 Mutation: 46 strains or lines available

References

• Original: J:77809 Ishii I, et al., Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. J Biol Chem. 2002 Jul 12;277(28):25152-9
• All: 16 reference(s)