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Gata2tm2Sho
Targeted Allele Detail
Nomenclature
Symbol: Gata2tm2Sho
Name: GATA binding protein 2; targeted mutation 2, Stuart Orkin
MGI ID: MGI:2183390
Synonyms: GATA-2KI, GATA-2V296G
Gene: Gata2  Location: Chr6:88193891-88207032 bp, + strand  Genetic Position: Chr6, 39.2 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77724
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA valine to glycine substitute at amino acid 296 (V296G) of exon 4, a floxed neo cassette insertion in the downstream intron, and a loxP site upstream of exon 4, were introduced to the gene via homologous recombination. The V296G mutation disrupts the FOG-binding region without affecting DNA-binding ability. The neo cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. (J:77724)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata2 Mutation:  20 strains or lines available
References
Original:  J:77724 Chang AN, et al., GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9237-42
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory