Tbp^tm1Ees
Targeted Allele Detail

Summary

• Symbol: Tbp^tm1Ees
• Name: TATA box binding protein; targeted mutation 1, Edward E Schmidt
• MGI ID: MGI:2183358
• Gene: Tbp Location: Chr17:15720150-15737689 bp, + strand Genetic Position: Chr17, 8.95 cM
• Alliance: Tbp^tm1Ees page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77714
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The majority of exon 3 was replaced with 2 tandem copies of the FLAG epitope tag and a loxP-flanked MC1-neo cassette was inserted 2.5 kb upstream of the promoter via homologous recombination. (J:77714)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbp Mutation: 11 strains or lines available

References

• Original: J:77714 Hobbs NK, et al., Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental beta2m-Dependent Interactions with the Maternal Immune System. Cell. 2002 Jul 12;110(1):43-54
• All: 1 reference(s)