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Mapk8ip1tm1Rjd
Targeted Allele Detail
Nomenclature
Symbol: Mapk8ip1tm1Rjd
Name: mitogen-activated protein kinase 8 interacting protein 1; targeted mutation 1, Roger J Davis
MGI ID: MGI:2183313
Synonyms: Jip1-
Gene: Mapk8ip1  Location: Chr2:92214021-92231608 bp, - strand  Genetic Position: Chr2, 50.99 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77616
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3, encoding the JNK-binding domain, was replaced with a neomycin selection cassette. Western blot analysis of brain tissue showed an absence of encoded protein in homozygous mutant mice. (J:77616)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mapk8ip1 Mutation:  20 strains or lines available
References
Original:  J:77616 Whitmarsh AJ, et al., Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev. 2001 Sep 15;15(18):2421-32
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory