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Tnfrsf11atm1Wjb
Targeted Allele Detail
Nomenclature
Symbol: Tnfrsf11atm1Wjb
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator; targeted mutation 1, William J Boyle
MGI ID: MGI:2183226
Synonyms: RANK-
Gene: Tnfrsf11a  Location: Chr1:105780718-105847981 bp, + strand  Genetic Position: Chr1, 49.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77636
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA portion of exon 2 and all of exon 3 was replaced with a neomycin selection cassette. The deleted region encoded approximately one and one half of the amino-terminal TNFR-like cysteine-rich domain, comprised of residues 34 through 96. Northern blot analysis confirmed the absence of normal transcript, while the results of a Western blot analysis of intestinal lysates using antibodies raised against the extracellular domain of the endogenous protien indicated a lack of protein. (J:77636)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf11a Mutation:  24 strains or lines available
References
Original:  J:77636 Li J, et al., RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1566-71
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory