Gabra5^tm1Uru
Targeted Allele Detail

Summary

• Symbol: Gabra5^tm1Uru
• Name: gamma-aminobutyric acid type A receptor subunit alpha 5; targeted mutation 1, Uwe Rudolph
• MGI ID: MGI:2183169
• Gene: Gabra5 Location: Chr7:57057420-57159807 bp, - strand Genetic Position: Chr7, 33.52 cM
• Alliance: Gabra5^tm1Uru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77343
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A point mutation was introduced into codon 105 (exon 4) resulting in the substitution of histidine with arginine (H105R). The targeting vector also contained a floxed neomycin cassette in intron 3 for selection. Mice carrying this allele were bred with transgenic mice expressing cre recombinase to generate Gabra5^tm1.1Uru. (J:77343)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra5 Mutation: 32 strains or lines available

References

• Original: J:77343 Crestani F, et al., Trace fear conditioning involves hippocampal alpha5 GABA(A) receptors. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8980-5
• All: 2 reference(s)