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Hrh1Bphs-r
Spontaneous Allele Detail
Nomenclature
Symbol: Hrh1Bphs-r
Name: histamine receptor H1; B pertussis induced histamine sensitization, resistant
MGI ID: MGI:2182954
Synonyms: Bphsh
Gene: Hrh1  Location: Chr6:114397936-114483296 bp, + strand  Genetic Position: Chr6, 53.05 cM
Mutation
origin
Strain of Origin:  C3H/HeJ or CBA/J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Nucleotide substitutions
 
Mutation detailsThis allele confers resistance to Bordetella pertussis induced histamine sensitization and occurs in strains C3H/HeJ and CBA/J. These strains carry three concordant amino acid changes in the predicted protein sequence (L263P, M313V and S331P) that are in the third intracellular loop and are postulated to be associated with signal transduction function. (J:77938)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hrh1 Mutation:  20 strains or lines available
Notes
Mice homozygous for this allele do not die from hypotensive and hypovolemic shock induced by vasoactive amine challenge after pertussis toxin sensitization (J:77938).
References
Original:  J:4933 Sudweeks JD, et al., Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6. Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3700-4
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory