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Adcyap1tm1Aba
Targeted Allele Detail
Nomenclature
Symbol: Adcyap1tm1Aba
Name: adenylate cyclase activating polypeptide 1; targeted mutation 1, Akemichi Baba
MGI ID: MGI:2182878
Synonyms: PACAP-
Gene: Adcyap1  Location: Chr17:93199422-93205485 bp, + strand  Genetic Position: Chr17, 60.67 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72576
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of the 5' portion of exon 5 with a PGK-neo cassette via homologous recombination. RT-PCR analysis using primers to exons 3-4 and exons 3-5 did not detect gene expression in the midbrain and diencephalons of homozygous mutant animals. In situ hybridization of parasagittal brain sections from homozygous mutants using a probe to the deleted portion of the gene did not detect gene expression. The null allele was further demonstrated by radioimmunoassay (RIA) of brain samples from homozygous mutant animals, which did not detect protein product. (J:72576)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcyap1 Mutation:  4 strains or lines available
References
Original:  J:72576 Hashimoto H, et al., Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13355-60
All:  21 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory