About   Help   FAQ
Targeted Allele Detail
Symbol: Adcyap1tm1Aba
Name: adenylate cyclase activating polypeptide 1; targeted mutation 1, Akemichi Baba
MGI ID: MGI:2182878
Synonyms: PACAP-
Gene: Adcyap1  Location: Chr17:93199422-93205485 bp, + strand  Genetic Position: Chr17, 60.67 cM
Germline Transmission:  Earliest citation of germline transmission: J:72576
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of the 5' portion of exon 5 with a PGK-neo cassette via homologous recombination. RT-PCR analysis using primers to exons 3-4 and exons 3-5 did not detect gene expression in the midbrain and diencephalons of homozygous mutant animals. In situ hybridization of parasagittal brain sections from homozygous mutants using a probe to the deleted portion of the gene did not detect gene expression. The null allele was further demonstrated by radioimmunoassay (RIA) of brain samples from homozygous mutant animals, which did not detect protein product. (J:72576)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcyap1 Mutation:  13 strains or lines available
Phenotypic Similarity to Human Syndrome: non-Sjogren's type aqueous-deficient dry eye syndrome J:240066.
Original:  J:72576 Hashimoto H, et al., Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP). Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13355-60
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory