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Targeted Allele Detail
Symbol: Per2tm1Drw
Name: period circadian clock 2; targeted mutation 1, David R Weaver
MGI ID: MGI:2182832
Synonyms: mPer2ldc, Per2-, Per2m
Gene: Per2  Location: Chr1:91343704-91387046 bp, - strand  Genetic Position: Chr1, 46.13 cM, cytoband C5
Germline Transmission:  Earliest citation of germline transmission: J:69626
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 5 and a portion of exon 6 were replaced with a neomycin selection cassette. Several transcript forms produced from the targeted allele were identified in homozygous mutant mice via RT-PCR and RACE analyses of brain RNA. The different transcripts involved aberrant splicing of exon 4 to a pseudoexon in intron 4, to a cryptic splice site within neo, and to exon 7. In spite of the transcripts having in-frame regions, normal protein was undetected in by immunohistochemical staining of superchiasmatic nuclei over a 24 hour period. (J:69626)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Per2 Mutation:  46 strains or lines available
Original:  J:69626 Bae K, et al., Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock. Neuron. 2001 May;30(2):525-36
All:  42 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory