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Targeted Allele Detail
Symbol: Hist1h1etm1Ais
Name: histone cluster 1, H1e; targeted mutation 1, Art I Skoultchi
MGI ID: MGI:2182777
Synonyms: H1e-
Gene: Hist1h1e  Location: Chr13:23621755-23622502 bp, - strand  Genetic Position: Chr13, 9.83 cM, cytoband A3.2
Germline Transmission:  Earliest citation of germline transmission: J:72858
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region of the gene was replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by reverse-phase HPLC analysis of liver histone extracts. (J:72858)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hist1h1e Mutation:  4 strains or lines available
Original:  J:72858 Fan Y, et al., Individual somatic h1 subtypes are dispensable for mouse development even in mice lacking the h1(0) replacement subtype. Mol Cell Biol. 2001 Dec;21(23):7933-43
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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