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Nfatc2tm1Srf
Targeted Allele Detail
Nomenclature
Symbol: Nfatc2tm1Srf
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2; targeted mutation 1, Edgar Serfling
MGI ID: MGI:2182770
Synonyms: NF-ATp-
Gene: Nfatc2  Location: Chr2:168476410-168601657 bp, - strand  Genetic Position: Chr2, 88.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45252
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details470 base pairs of exon 2 and approximately 400 base pairs of intron 2 were replaced with a neomycin selection cassette. The insertion of the neo gene removed a splice site and introduced stop codons into all three reading frames. Western blot analysis of splenocyte nuclear protein extracts confirmed the absence of normal encoded protein in homozygous mutant mice. (J:45252, J:110686, J:150931)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfatc2 Mutation:  22 strains or lines available
References
Original:  J:45252 Heyer J, et al., Inefficient termination of antigen responses in NF-ATp-deficient mice. Immunobiology. 1997 Dec;198(1-3):162-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory