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Aff2tm1Dln
Targeted Allele Detail
Nomenclature
Symbol: Aff2tm1Dln
Name: AF4/FMR2 family, member 2; targeted mutation 1, David L Nelson
MGI ID: MGI:2182641
Synonyms: Fmr2 KO
Gene: Aff2  Location: ChrX:69360294-69868037 bp, + strand  Genetic Position: ChrX, 35.53 cM, cytoband A5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76005
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacing part of exon 1 with a lacZ-PGK-neo cassette via homologous recombination resulting in fusion of the lacZ gene 16 bp upstream of the ATG start codon. Gene expression was absent in homozygous mutant animals as shown by RT-PCR analysis using different sets of primers to the gene. (J:76005)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 34 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aff2 Mutation:  11 strains or lines available
References
Original:  J:76005 Gu Y, et al., Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice. J Neurosci. 2002 Apr 1;22(7):2753-63
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory