Phenotypes associated with this allele

• Allele Symbol: Aff2^tm1Dln
• Allele Name: targeted mutation 1, David L Nelson
• Allele ID: MGI:2182641
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Aff2^tm1Dln/Y	involves: 129/Sv * C57BL/6	MGI:3655954

Genotype
MGI:3655954

ot1

• Allelic Composition: Aff2^tm1Dln/Y
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:76005 )

♂ • no evidence of prenatal mortality

♂ • 15% male mortality within the first 13 months of life, mostly from 4 to 7 months of age

growth/size/body

decreased body size ( J:76005 )

♂ • some, but not all, homozygotes are much smaller than controls

behavior/neurological

abnormal cued conditioning behavior ( J:76005 )

♂ • considerably less "freezing" than in controls when exposed to a conditioned (auditory) stimulus

abnormal spatial learning ( J:76005 )

♂ • more time is required to find the platform in the Morris water maze test but a spatially biased search pattern is used

decreased thermal nociceptive threshold ( J:76005 )

♂ • shorter latency to first hind-limb response in a hot plate test

nervous system

abnormal CNS synaptic transmission ( J:76005 )

♂ • baseline hippocampal CA1 synaptic transmission is normal

♂ • normal input-output functioning of CA1 presynaptic fiber volley

♂ • normal paired pulse facilitation at interpulse intervals of 20-300 msec

abnormal excitatory postsynaptic potential ( J:76005 )

♂ • increased slope of the fEPSP

enhanced long-term potentiation ( J:76005 )

♂ • lasting up to three hours after tetanization