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Ungtm1Tld
Targeted Allele Detail
Nomenclature
Symbol: Ungtm1Tld
Name: uracil DNA glycosylase; targeted mutation 1, Tomas Lindahl
MGI ID: MGI:2182610
Synonyms: ung-
Gene: Ung  Location: Chr5:114130386-114139323 bp, + strand  Genetic Position: Chr5, 55.97 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63056
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe insertion of a neomycin selection cassette disrupted exon 4, which encodes residues of the uracil-binding pocket. The insertion was designed to impair the production of both nuclear and mitochondrial isoforms. Uracil-DNA glycosylase activity was shown to be markedly reduced in cell extracts from homozygous mutant mice. The residual activity was not inhibited by antibodies raised against the encoded protein. (J:63056)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ung Mutation:  17 strains or lines available
References
Original:  J:63056 Nilsen H, et al., Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication. Mol Cell. 2000 Jun;5(6):1059-65
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory