Plpp2^tm1Grid
Targeted Allele Detail

Summary

• Symbol: Plpp2^tm1Grid
• Name: phospholipid phosphatase 2; targeted mutation 1, Tom Gridley
• MGI ID: MGI:2182608
• Gene: Plpp2 Location: Chr10:79362258-79369621 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Plpp2^tm1Grid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64972
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding the amino acids 47 through 160 was replaced by a neomycin selection cassette inserted by homologous recombination. The deleted region encompassed the second and third transmembrane domains as well as the first domain of the conserved phosphatase superfamily motifs. Northern blot analysis demonstrated an absence of transcript in homozygous mutant mice. (J:64972)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plpp2 Mutation: 22 strains or lines available

References

• Original: J:64972 Zhang N, et al., Mice mutant for ppap2c, a homolog of the germ cell migration regulator wunen, are viable and fertile. Genesis. 2000 Aug;27(4):137-40
• All: 1 reference(s)