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Targeted Allele Detail
Symbol: Festm2Mcs
Name: feline sarcoma oncogene; targeted mutation 2, M Celeste Simon
MGI ID: MGI:2182589
Synonyms: c-fesdeltac
Gene: Fes  Location: Chr7:80377756-80387946 bp, - strand  Genetic Position: Chr7, 45.65 cM
Mouse Generated:  Earliest citation of chimera generation: J:76509
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2.5 kb region of the gene spanning exons 12-14 were replaced with a PGK-neo cassette via homologous recombination. The gene targeting event results in deletion of the C-terminal SH2 domain and the ATP-binding site of the tyrosine kinase domain (amino acids 497-607). Homozygous mutant embryonic stem cells were identified via Southern blot analysis. (J:76509)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fes Mutation:  19 strains or lines available
Original:  J:76509 Hackenmiller R, et al., Truncation of c-fes via gene targeting results in embryonic lethality and hyperproliferation of hematopoietic cells. Dev Biol. 2002 May 15;245(2):255-69
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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