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Festm1Mcs
Targeted Allele Detail
Nomenclature
Symbol: Festm1Mcs
Name: feline sarcoma oncogene; targeted mutation 1, M Celeste Simon
MGI ID: MGI:2182586
Synonyms: c-fes-
Gene: Fes  Location: Chr7:80377756-80387946 bp, - strand  Genetic Position: Chr7, 45.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64748
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe promoter and translation initiation codon were replaced with a PGK-neo cassette via homologous recombination. Homozygous mutant embryonic stem cells were identified by Southern blot analysis and Western blot analysis was used to confirm the absence of gene expression. (J:64748)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fes Mutation:  19 strains or lines available
References
Original:  J:64748 Hackenmiller R, et al., Abnormal Stat activation, hematopoietic homeostasis, and innate immunity in c-fes-/- mice. Immunity. 2000 Sep;13(3):397-407
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/20/2017
MGI 6.10
The Jackson Laboratory