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Nr4a1tm1Jmi
Targeted Allele Detail
Nomenclature
Symbol: Nr4a1tm1Jmi
Name: nuclear receptor subfamily 4, group A, member 1; targeted mutation 1, Jeffrey Milbrandt
MGI ID: MGI:2182325
Synonyms: classical Nur77-KO, NGFI-B-, NGFI-B (-), Nur77-
Gene: Nr4a1  Location: Chr15:101254269-101274795 bp, + strand  Genetic Position: Chr15, 56.64 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77686
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutation:    Insertion
 
Mutation detailsExon 2 was disrupted by the insertion of a neomycin resistance gene 300 bp downstream of the translational start site. A functional portion of the N-terminal domain of the full length gene is expressed. (J:77686, J:270260)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nr4a1 Mutation:  29 strains or lines available
References
Original:  J:77686 Lee SL, et al., Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77). Science. 1995 Jul 28;269(5223):532-5
All:  75 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory