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Mesp1tm3Ysa
Targeted Allele Detail
Nomenclature
Symbol: Mesp1tm3Ysa
Name: mesoderm posterior 1; targeted mutation 3, Yumiko Saga
MGI ID: MGI:2182080
Synonyms: Mesp1(-), Mesp1-null
Gene: Mesp1  Location: Chr7:79792241-79793788 bp, - strand  Genetic Position: Chr7, 45.16 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49903
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    Exons 1 and 2 were disrupted by the insertion of a PGK-neo cassette. (J:49903)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 22 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mesp1 Mutation:  11 strains or lines available
Notes
Chimera analysis in which double homozygous Mesp1tm3Ysa and Mesp2tm3(cre)Ysa mutant embryos were aggregated with wild-type embryos show that embryos develop normally, however double knock-out cells are scarcely seen in the anterior-cephalic and heart mesoderm, but they do contribute to the formation of somites, notochord, and gut, and the atrial appendage is exclusively composed of the mutant cells (J:62984).
References
Original:  J:49903 Saga Y, Genetic rescue of segmentation defect in MesP2-deficient mice by MesP1 gene replacement. Mech Dev. 1998 Jul;75(1-2):53-66
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory