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Kcnab1tm1Sva
Targeted Allele Detail
Nomenclature
Symbol: Kcnab1tm1Sva
Name: potassium voltage-gated channel, shaker-related subfamily, beta member 1; targeted mutation 1, Alcino J Silva
MGI ID: MGI:2181771
Synonyms: Kvbeta1.1-deficient
Gene: Kcnab1  Location: Chr3:65109384-65378223 bp, + strand  Genetic Position: Chr3, 30.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51147
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a PGK-neo cassette into codon 25 of exon 1 via homologous recombination. Northern and Western blot analysis of brain from homozygous mutant animals confirmed the absence of gene expression. (J:51147)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Kcnab1 Mutation:  18 strains or lines available
References
Original:  J:51147 Giese KP, et al., Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning. Learn Mem. 1998 Sep-Oct;5(4-5):257-73
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory