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Targeted Allele Detail
Symbol: Usf1tm1Msw
Name: upstream transcription factor 1; targeted mutation 1, Michele Sawadogo
MGI ID: MGI:2181678
Synonyms: Usf1(-)
Gene: Usf1  Location: Chr1:171411313-171419142 bp, + strand  Genetic Position: Chr1, 79.4 cM, cytoband H
Germline Transmission:  Earliest citation of germline transmission: J:46788
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details3.4 kb of the gene encoding amino acids 27-301 was deleted and replaced with a PGK-neo cassette via homologous recombination. The absence of gene expression in homozygous mutants was confirmed by electrophoretic mobility shift assay (EMSA) and Western blot analysis of nuclear extracts from mutant mouse embryonic fibroblasts (MEF). (J:46788)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Usf1 Mutation:  69 strains or lines available
Original:  J:46788 Sirito M, et al., Overlapping roles and asymmetrical cross-regulation of the USF proteins in mice. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3758-63
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory