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Targeted Allele Detail
Symbol: Ece2tm1Ywa
Name: endothelin converting enzyme 2; targeted mutation 1, Masashi Yanagisawa
MGI ID: MGI:2181668
Synonyms: ECE-2-
Gene: Ece2  Location: Chr16:20629851-20645915 bp, + strand  Genetic Position: Chr16, 12.48 cM, cytoband B1
Cardiac defects in Ece1tm1Reh/Ece1tm1Reh and Ece1tm1Reh/Ece1tm1Reh Ece2tm1Ywa/Ece2tm1Ywa embryos

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:62261
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 14 and 15, the latter of which encodes the essential conserved zinc-binding motif, were replaced with a neomycin selection cassette. RT-PCR analysis of total RNA extracted from homozygous mutant brain tissue showed an absence of expression. (J:62261)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ece2 Mutation:  6 strains or lines available
Original:  J:62261 Yanagisawa H, et al., Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development. J Clin Invest. 2000 May;105(10):1373-82
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory