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Stat5atm1Jni
Targeted Allele Detail
Nomenclature
Symbol: Stat5atm1Jni
Name: signal transducer and activator of transcription 5A; targeted mutation 1, James N Ihle
MGI ID: MGI:2181607
Synonyms: Stat5a-
Gene: Stat5a  Location: Chr11:100859351-100885169 bp, + strand  Genetic Position: Chr11, 63.77 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77412
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe first 2 exons of the gene were replaced with a hygromycin-B resistance cassette via homologous recombination. Immunoprecipitation and Western blot of liver extracts from homozygous mutant animals verified the absence of gene expression. (J:77412)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stat5a Mutation:  25 strains or lines available
Notes
ES cell line = E14 (129P2/OlaHsd) or RW4 (129X1/SvJ).
References
Original:  J:77412 Teglund S, et al., Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 1998 May 29;93(5):841-50
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory