Phenotypes associated with this allele
Allelic
Composition |
Stat5atm1Jni/Stat5atm1Jni
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Genetic
Background |
either: (involves: 129P2/OlaHsd) or (involves: 129X1/SvJ) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm1Jni mutation
(0 available);
any
Stat5a mutation
(48 available)
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adipose tissue
endocrine/exocrine glands
 |
• reduced alveolar development in response to pregnancy
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• reduced levels of alpha-lactalbumin and whey acidic protein
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integument
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• reduced alveolar development in response to pregnancy
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• reduced levels of alpha-lactalbumin and whey acidic protein
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm1Jni mutation
(0 available);
any
Stat5a mutation
(48 available)
Stat5btm2Jni mutation
(0 available);
any
Stat5b mutation
(33 available)
|
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immune system
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• induction of colony forming cells by Il3 reduced to 57% of controls
• induction of colony forming cells by Il5 reduced to 25% of controls
• induction of colony forming cells by GM-CSF reduced to 47% of controls
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• increased percentage of neutrophiles
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• due to a decreased percentage of lymphocytes
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• peripheral T cell deficiency
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endocrine/exocrine glands
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• few or no large corpora lutea form after ovulation
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reproductive system
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• few or no large corpora lutea form after ovulation
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adipose tissue
liver/biliary system
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• Major Urinary Protein undetectable in females and dramatically reduced in males
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growth/size/body
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• weight reduced 20-30% relative to controls in females
• weight reduced 30-40% relative to controls in males
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hematopoietic system
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• induction of colony forming cells by Il3 reduced to 57% of controls
• induction of colony forming cells by Il5 reduced to 25% of controls
• induction of colony forming cells by GM-CSF reduced to 47% of controls
|
|
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• increased percentage of neutrophiles
|
|
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• due to a decreased percentage of lymphocytes
|
|
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• peripheral T cell deficiency
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat5atm1Jni mutation
(0 available);
any
Stat5a mutation
(48 available)
Stat5btm2Jni mutation
(0 available);
any
Stat5b mutation
(33 available)
|
|
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mortality/aging
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• 40% of the mice die within the first few months
|
immune system
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• bone marrow cells die of apoptosis when cultured in WEHI-3 cell-conditioned media that normally supports mast cell differentiation
• mutant bone marrow cells fail to produce mast cells as wild-type bone marrow does when transferred into mast cell deficient kitw-v mice
• however, mast cells can be derived from bone marrow cells when cultured with IL-3 and SCF
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• mast cells are absent in these mice as determined by histology and flow cytometry
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• reduction of CD4+CD25+ suppressor T cells
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• bone marrow derived mast cells die of apoptosis when culture is supplemented with only low levels of IL-3 or SCF
• 80-fold more IL-3 or 50-fold more SCF is needed than controls to prevent apoptosis in cultured mast cells
• mast cells delay entering into S-phase when cultured with SCF or IL-3 taking almost twice as long as to reach half-maximal entry into S phase
• these mast cells survive and proliferate when cultured with IL-3 and SCF
|
hematopoietic system
|
|
• bone marrow cells die of apoptosis when cultured in WEHI-3 cell-conditioned media that normally supports mast cell differentiation
• mutant bone marrow cells fail to produce mast cells as wild-type bone marrow does when transferred into mast cell deficient kitw-v mice
• however, mast cells can be derived from bone marrow cells when cultured with IL-3 and SCF
|
|
|
• mast cells are absent in these mice as determined by histology and flow cytometry
|
|
|
• reduction of CD4+CD25+ suppressor T cells
|
|
|
• bone marrow derived mast cells die of apoptosis when culture is supplemented with only low levels of IL-3 or SCF
• 80-fold more IL-3 or 50-fold more SCF is needed than controls to prevent apoptosis in cultured mast cells
• mast cells delay entering into S-phase when cultured with SCF or IL-3 taking almost twice as long as to reach half-maximal entry into S phase
• these mast cells survive and proliferate when cultured with IL-3 and SCF
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cellular
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• bone marrow cells die of apoptosis when cultured in WEHI-3 cell-conditioned media that normally supports mast cell differentiation
• mutant bone marrow cells fail to produce mast cells as wild-type bone marrow does when transferred into mast cell deficient kitw-v mice
• however, mast cells can be derived from bone marrow cells when cultured with IL-3 and SCF
|
Analysis Tools